How CBD can affect chronic inflammation

Causes of Inflammation

Inflammation is a reaction to trauma or an immune event in your body, which triggers an immune response. Inflammation comes in two distinct forms: acute and chronic. Acute is the kind that you probably know about, like when you bump your elbow or when you get a scratch or a cut and it gets swollen. That’s simple cytokine activity triggering immune cells to fight a given trauma. 

Then we have chronic inflammation. It’s the inflammation that’s occurring in our body all the time. This happens when our cells become sick and our body triggers an immune response, which then escalates into a feedback loop where the immune system responds, even more, yielding to chronic inflammation. 

When we talk about anti-inflammatory processes in the body, we think about something known as a nonsteroidal anti-inflammatory such as aspirin, or ibuprofen. Yes, those do combat inflammation. Here’s how they actually work. They act upon something known as the cyclooxygenase enzymes, COX1, and COX2 for short. 

Cyclooxygenase enzymes are a way to actually slow down inflammation by inhibiting them. The problem is nonsteroidal anti-inflammatories are hard on the gut. This is because they stop the production of both COX1 and COX2. One of those cyclooxygenase enzymes we need to protect our gut. A low amount of inflammation in the gut is actually normal for the healthy functioning of your digestive system.

The Endocannabinoid system to the rescue

Now let’s talk more about how CBD directly affects inflammatory responses within the body. Every mammal has a network of receptors called endocannabinoids. They’re endogenous cannabinoids. A lot of times, when we think of cannabinoids, we think of only something that’s coming from cannabis, something that’s illegal, or something that really is an exogenous thing coming in. 

The reality is, we have endogenous cannabinoids. They’re called endocannabinoids and they have an anti-inflammatory effect on the body. They are a very natural occurrence of fatty acid metabolism.

This endocannabinoid system is a naturally occurring member of what is called the eicosanoid families. If you’ve ever bought a fish oil pill or any kind of omega 3, you’ve seen eicosapentaenoic acid, or EPA, on the label, an anti-inflammatory fat that modulates inflammation and helps with a variety of other internal functioning.

How fatty acids play a role

These endocannabinoids are naturally occurring members of that superfamily. In this particular case, endocannabinoids are derived from long-chain fatty acids. When they’re actually needed, they’re released by the neurons. The neurons actually see some inflammation or they see something, they’re going to release more of these to modulate it.

What are Cytokines?

Let’s take it a little bit further to understand how this works. Cytokines are small signaling proteins that are a vital component of a healthy immune system. Cytokines will instruct specific immune cells to reduce inflammation. CBD actually modulates the cytokine production. CBD works by reducing the inflammation in overactive immune cells. 

CBD regulates cytokine activity 

What CBD does is reduces cytokine activity of these helper T cells so they are not activated in a negative way. This is extremely important because overactive T cells will run wild and attack the wrong kind of cells thus leading to increased inflammation. You can see how this can lead to a massive amount of joint pain, brain fog, and digestive discomfort.

Anandamide is a naturally occurring cannabinoid and CBD oil helps to produce more of it. CBD also reduces the cytokine activity that would normally inhibit it. We’re talking about the cytokine activity associated with Tumor necrosis factor 1 alpha, TNF1-a, very common in the world of inflammation. The body’s ability to fight off the production of anandamide can happen by reducing TNF1-a. All this means is by reducing the cytokine activity of these two things, we are allowing endocannabinoids to do their jobs better.

Anandamide is very much responsible for creating bliss within the body, reducing inflammation in the joints, but also reducing inflammation in the brain. It truly is known as the bliss product of the body, because that’s the sensation that best describes what anandamide does. How exactly does anandamide do that? Well, it’s because it holds the key to be able to turn off nuclear factor kappa B, or at least greatly reduce it. 

Nuclear Factor Kappa B

Nuclear factor-kappa B is a widely researched inflammatory substance within the body. Kappa B is essentially the main control mechanism of inflammation. So by reducing the amount of Kappa B in our system we will be able to directly reduce the amount of inflammation. So really anandamide is one of the keys to actually getting rid of this problem where our bodies are getting so accustomed to inflammation that we’re just adapting to become these inflamed creatures.

Conclusion

All CBD oils interact with our body’s own endocannabinoid system. It’s important that you know that at the end of the day, CBD oil is a solid way to modulate and reduce inflammation in the body without acting about the cyclooxygenase enzymes that are going to destroy your gut and lead to a lot of other damaging things in your life. Always consult with your doctor before starting any CBD health regimen as CBD oil may interact with some existing medications you may be taking.

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How CBD Affects the Brain

What is CBD?

CBD is a natural compound extracted from the cannabis or hemp plant and it comes infused in oils, sprays, pills, gummies etc. There are many ways to consume CBD. One of the most popular ways is in the form of CBD oil. The CBD oil comes in dropper bottles typically in sizes from 1oz to 2 oz. 

To administer a dose you would take in the oil with the dropper and squeeze out the desired amount of drops directly under the tongue. Now hold for 30-90 seconds. The mucus membranes of your mouth need a little time to absorb and process the oil. This is called the sublingual method and is one of the fastest ways of getting CBD absorbed into the bloodstream other than vaping.

An interesting feature of CBD is that it doesn’t make you high. That’s because CBD doesn’t have THC which is a component in marijuana that activates receptors in the brain to get you that good ‘ole fashioned high feeling.

This makes CBD an option for those looking to relieve anxiety, pain, brain fog, inflammation, and many other health symptoms because it doesn’t have the psychoactive effects of marijuana. 

CBD influences brain activity by activating specific neurons and receptors in the brain such as dopamine and serotonin. So when someone consumes CBD, it binds to these receptors and specific neurons like a key fitting into a lock when CBD has bound to these receptors in the brain.

Here are 4 ways that CBD affects the brain:

1. Reducing Blood Flow 

A study published by the Journal of psychopharmacology in 2000 showed that CBD reduces blood flow in areas of the brain that are linked with anxiety. This reduction in blood flow calmed the participants down and changed the way they responded to anxiety. 

2. Managing Pain

Scientists have found that CBD changes the way in which receptors respond to pain signals we receive so it makes it easier to control pain and manage inflammation in the body. Additionally, they found that CBD caused the body to produce more natural cannabinoids which made it easier to manage chronic pain symptoms for many of its users. 

3. Reducing Oxidative Damage 

Oxidative damage is the imbalance between free radicals and antioxidants in the body and the way in which our bodies manage this oxidative stress plays a huge role in our overall health.  Research has found that CBD acts on the receptors in the brain to decrease the level of oxidative damage. When that happens it helps our body produce more antioxidants that help the body heal, release tension, and release stress from the brain faster.

4. CBD has Antipsychotic Properties 

Research has found that CBD helps to reduce psychotic symptoms in those with mental disorders such as schizophrenia. With these antipsychotic properties, it was found that CBD is able to actually boost the overall mood of its users. 

Conclusion

There are many positive health effects that CBD has on the brain and the body. Although the clinical research regarding CBD is still relatively new, the findings so far look very promising. The passing of the 2018 Farm Bill has played a large role in the increased amount of CBD clinical research studies now in the works. In the meantime, CBD has already made a monumental impact throughout the wellness industry as more people are discovering the benefits for themselves.

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CBD: No Longer the Next Big Thing, Just the Big Thing

How popular is CBD and what are its health benefits?

Martha Stewart has jumped on the bandwagon, Mandy Moore uses it to get through high heel torture on the red carpet, and Dr Sunjay Gupta gave it his seal of approval on the Dr Oz Show. It’s clear: CBD is getting more attention and more popular every day.

This naturally derived chemical compound, which not so long ago existed within a pretty niche market has now exploded onto store shelves, into cafes, and as part of recommended therapeutic treatments. You can now get CBD as an additional extra in your coffee, a supplement for your post-workout smoothie, as well as a herbal, non-medicinal option for a variety of conditions both physical and mental. It’s no wonder then CBD has gained so much traction in the last five years, being well on course to take a prominent place in the mainstream wellness industry. 

A Growing Industry

In 2018 around $620 million worth of CBD oil products were sold in the US; in 2019 this figure grew exponentially to $4 billion, and with these numbers projected to climb to $24.4 billion by 2025  there are no signs of this industry slowing any time soon. Combine these estimates with the fact that retail giants like CVS and Walgreens continue to introduce CBD products into their stores, and it’s plain to see that this natural molecule is going mainstream. 

According to some recent surveys, an estimated 64 million Americans have used CBD in the last two years, whilst around a third of Americans have used it at least once or more. An interesting fact behind these figures is that it’s not just one single demographic that’s responsible either: the use of CBD cuts across all age groups. 40% of twenty-year-olds have tried CBD, but so have 15% in the 60+ age category, with adults in the over 50’s market being the fastest-growing segment at 25% just last year. 

So what’s the reason for this huge growth in popularity? Whilst CBD comes from the cannabis plant, it doesn’t make you high, and as such, its medical use far outweighs the recreational side. Indeed a study found that the vast majority of clinicians (92%) have said a patient has mentioned using CBD for a medical conditions, so it’s no surprise this health segment continues to dominate the CBD market with many people taking it to manage a suite of various conditions. So what exactly are CBD’s top health benefits?

What Are the Health Benefits of CBD?

1. Pain and Inflammation 

Researchers believe that CBD stimulates the activity of a cell-signalling system in the body (the endocannabinoid system or ECS) in a way that relieves pain and reduces inflammation. A study from 2020 involved applying topical CBD to patients with neuropathic pain (i.e. related to nerve damage) in their legs. After one month, “researchers noted a statistically significant reduction in intense pain, sharp pain, cold and itchy sensations in those using CBD oil”, all without side effects. Many sufferers of arthritis and chronic pain take CBD on a regular basis, finding it an effective way to alleviate symptoms whilst avoiding some of the adverse reactions that usually occur when taking conventional drugs.

2. Reduces Anxiety and Depression

A Consumer Report survey from 2019 found the most popular use of CBD was to reduce stress, anxiety and depression. Anxiety and depression is often treated with powerful pharmaceuticals that can be addictive as well as the cause of many unpleasant side-effects such as insomnia, sexual dysfunction and migraines. CBD on the other hand has been found to significantly reduce stress, treat insomnia and decrease levels of anxiety in children with PTSD and with less extreme side-effects. This is again related to CBD’s reaction with the ECS, but also its positive effects on the hippocampus, the part of the brain largely responsible for our emotions and mood. 

3. Neuroprotection

There are a number of neurodegenerative diseases for which CBD can help reduce symptoms. Various studies have shown a correlation between CBD dosages and improved ALS, Parkinson’s disease and multiple sclerosis symptoms, mostly based on the fact that CBD can help reduce the neurological damage associated with all of these conditions. More studies are needed, but so far the outlook is hopeful.  

4. Manages insomnia

Many advocates of CBD use it to gain a better night’s sleep. The underlying cause of a person’s insomnia could be any number of conditions: anxiety-induced, as a result of Parkinson’s disease, or chronic pain. With these conditions being ones that can be calmed by CBD, it follows that it could help you sleep better too. Even without those conditions however, certain studies have shown that CBD will help you sleep better and improve your insomnia condition regardless of the cause. Whether you have insomnia or not, high cortisol levels in the body at night are associated with a broken night’s sleep, and one study showed that taking CBD reduces cortisol levels, suggesting it acts much like a natural sedative.

5. Epilepsy

Epidiolex was the first FDA-approved CBA-based medication, and prescribed for patients with two rare forms of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome. The drug went through all the proper channels of rigorous testing and clinical trials and has found to be effective in reducing and controlling seizures. Further studies are also looking into the possibility of adding CBD to common antiepileptic (i.e. anti-seizure) drugs and seeing how successful they are against treatment-resistant epilepsy suffered in children.

6. Acne and Other Inflammatory Skin Conditions

As we’ve seen, CBD oil displays strong anti-inflammatory effects, interacting with the endocannabinoid system to achieve positive results.The ECS is also found on the skin, and as such CBD has been shown to improve associated skin problems such as psoriasis, acne and itchy skin. More studies are taking place but early research shows CBD can also interact with the sebaceous glands to prevent or improve acne.

Summary

CBD is used by millions across the world for a variety of reasons, and find it an effective natural product that either supplements or replaces traditional drugs that could otherwise cause more severe side-effects or lead to serious addictions.

Whether it’s for pain relief, managing seizures or reducing anxiety levels, it’s apparent that CBD has a number of applications. Studies are still ongoing about its helpfulness in other treatments, but should you have any questions about using CBD in relation to a condition, it’s always recommended to speak with a doctor for further information.

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Debunking the Top 3 CBD Myths

CBD is everywhere and in everything. You can find the popular plant extract in yummy gummy candies, cocktails, and skincare products. The hemp compound is safe, effective, and easy to use. Here are a few of the myths about CBD and why they’re wrong.

Myth 1: CBD Oil Will Get You High

Many people confuse CBD and THC. CBD or cannabidiol is a non-psychoactive compound found in the hemp plant. THC is a cannabinoid primarily in cannabis that causes some users to experience a “high” from the psychoactive properties. 

Hemp contains less than 0.3% of THC, which isn’t enough to produce a “high.” Instead, CBD oils offer a slight calming effect that may reduce stress levels naturally and help consumers sleep better. Hemp extracts are also available in a broad-spectrum formula that removes the small amount of THC. 

Myth 2: Science Doesn’t Support CBD Claims 

The science supports CBD claims. There are hundreds of studies that involve animals and lab testing. A quick search of research through the National Institute of Health returns thousands of results. Since 2018, when the U.S. legalized hemp production and CBD, studies have more than doubled. Also, human clinical trials are expanding fast. These are being conducted to verify earlier results with animals and lab studies. In early 2020, the DEA rescheduled CBD to allow more patients access to Epidiolex, the only approved cannabidiol treatment. This change is also fueling more studies for people without seizures.  

Myth 3: All CBD Oil Brands are the Same 

This might be the second biggest myth regarding CBD and one that isn’t discussed enough. Hemp extracts aren’t strictly regulated in the U.S. The FDA won’t begin testing individual brands and products until early 2021, over two years after Congress legalized hemp and CBD. In the meantime, brands oversee their own in-house and third-party testing without any oversight. 

While hemp is a natural botanical, there’s a lot that can go wrong between the cultivation, culling, processing, and storing of items infused with CBD oil. The plant absorbs any compounds in the soil, good or bad. Cultivators that try to improve their crop with pesticides, insecticides, and other chemicals may not realize the plants absorb the dangerous compounds. 

Additionally, if the soil is full of heavy metals, that can also taint the final product. Flowers that aren’t properly dried can develop mold that can end up in the oil and more problems can arise during the extraction process. For example, some methods can leave behind solvents in the oil. All of these situations can produce dangerous products.

Responsible brands send their hemp-infused sales items to a third-party lab to check for dangerous chemicals, heavy metals, and other contaminants. The independent location provides a certificate of analysis (COA) that verifies the safety of the brand’s items. 

CBD products, including oils, vapes, topicals, and edibles, are safe for regular use and have many potential benefits. The naturally occurring plant chemical is widely studied, and there are several clinical research trials in progress. Clinicians are working to verify how CBD oil and similar compounds found in the hemp plant help people and how to use them to improve overall wellness.

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The Rise of Anxiety and Depression and CBD Response

Anxiety and depression share coexisting symptoms. They are both debilitating conditions and can lead to irrational thoughts and fears that interfere with daily life. While anxiety is the exhibition of irrational fear, depression is the sustained feeling of sadness.

The number of people suffering from anxiety is on another dimension by itself, but research puts the number of people suffering from depression worldwide at about 322 million

Over 322 million people of the world’s 7 billion inhabitants suffer from some form of depression. In the US, a report from the National Institute of Mental Health indicates that around 15.7 million adults age 18 or older (6.7% of adults in the US) had experienced at least one major depressive episode in 2014. 

Signs of Chronic Anxiety and Depression

Anxiety and depression share overlapping signs and symptoms, and they can include each or a combination of the following;

  • Difficulty concentrating, making decisions, or recalling.
  • Muscle tension.
  • Pain, aches, cramps, or gastrointestinal problems without any apparent cause.
  • Changes in appetite or weight.
  • Difficulty sleeping, waking early, or oversleeping.
  • Loss of interest in recreational activities or hobbies.
  • Persistent feelings of sadness, anxiety, or emptiness.
  • Feeling hopeless or pessimistic.
  • Anger, irritability, or restlessness.

In this article, we shall use anxiety and depression interchangeably to mean the same thing.

CBD to the Rescue

If you have friends or family dealing with anxiety and don’t seem to get better with conventional treatment therapy, all hope is not lost. Individuals coping with anxiety can find some respite when they use CBD. The evidence shows that using CBD for depression leads to more stabilized moods, sleep, and appetite.

What is CBD?

Cannabidiol (CBD) is one of the most talked-about cannabinoids from the Cannabis plant. The substance is one of the over 540 chemical compounds in the plant, including THC, terpenes, flavonoids, and plant parts.

What the research says

Research underway suggests that CBD oil has powerful pharmacological effects and can impact individuals dealing with anxiety and depression. 

Research indicates that CBD interacts with the endocannabinoid receptors in the brain and supports it to maintain a balance in the body system and bodily functions. CBD helps to numb the feelings of anxiety, allowing you to stay balanced and happy.

According to a recent research study conducted to investigate CBD’s role in treating various anxiety disorders, the authors were able to establish a positive case for CBD in the management of anxiety and depression. 

The authors examined eight studies relating to CBD’s role in treating anxiety and depression. They found evidence supporting CBD as an effective monotherapy or complementary therapy for treating generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorders.

How to use CBD

There are several ways to use CBD. The substance comes in various forms; oils, vapes, topicals, and edibles. Depending on the purpose of using CBD, you would choose any product types to serve you best. For anxiety management, you would find vapes and edibles the most suitable for you. However, for those who do not smoke or are averse to smoking, CBD edibles are the most obvious choice.

CBD oil tincture for management of anxiety and depression

CBD oil tincture is suitable for everyone and can help people with anxiety consume CBD in a convenient and relaxing manner. In this method, the CBD oil comes in a bottle with a measured dose dropper. All you do is pull some of the CBD oil in the dropper, and place the desired dosage under your tongue for 20-30 seconds. For newbies, drops are a great way to get started on your CBD journey. 

How to take CBD for Anxiety

If you are just getting started on a CBD treatment therapy, you should start with low doses and work your way up. It is best to measure your body’s reaction to CBD before you dive into the deep end.

CBD Legality

Hemp-derived CBD (with less than 0.3 percent THC) is legal on the federal level ever since the 2018 Farm Bill was signed into law.  It is important to note that the FDA has still not approved CBD for use in food and beverage products. Check your state’s laws and those of anywhere you travel. Keep in mind that non-prescription CBD products are not FDA-approved and may be inaccurately labeled.

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CBD and Coffee

In this article, we will discuss a subject that’s near and dear to my heart—CBD and coffee.

One of the questions that I get asked all the time is about CBD and coffee interaction. Many people think that the CBD relaxes you and the caffeine gets you all amped up and ready for the day so what happens when you put the two together?

What happens is something beautiful. One of the things that caffeine does is it binds with your brain’s adenosine receptors.  Adenosine is normally responsible for preparing your body for sleep so you know it’s something that grows throughout the day and increases your desire for sleep. 

When you drink coffee, the caffeine then goes and binds with that adenosine receptor preventing your own adenosine from connecting there and thereby preventing that drowsiness from kicking into gear.

When caffeine binds to that adenosine receptor actually the opposite occurs–your neuron activity is increased and adrenaline is released and that’s why you feel energetic, aware, and awake. That sensation that we all know and love from a nice cup of coffee that is actually adrenaline kicking in.

Unfortunately, there are some negative side effects that can be experienced with that increase in adrenaline. You may know that adrenaline is responsible for that fight-or-flight response, well that’s your sympathetic nervous system kicking into gear.

For people that might be sensitive to caffeine, or that may have had a few too many cups throughout the day, that can induce a sense of jitteriness or edginess that could be very uncomfortable.

Luckily, one of the many things that CBD oil does within the body is to stimulate your serotonin receptors which produce a bit of a calming, anti-anxiety sensation. Therefore, this counteracts the effects of that negative fight-or-flight response caused by the adrenaline and the caffeine and you can still get the mental clarity minus the jittery edginess.

That’s just a brief glimpse into the science behind why CBD and coffee work well together. In summary, it’s because the caffeine and coffee put your body into a bit of fight-or-flight response and the CBD actually has anti-anxiety effects to calm that sensation.

Another reason that CBD and coffee go so well together is a little bit more cultural or habitual. Many people turn to coffee and espresso-based drinks throughout the day to keep them going, it’s part of their daily ritual and something that they can’t imagine living without. Caffeine is one of humanity’s favorite drugs.  

So what better place to add something good into your daily routine by slipping some CBD into your coffee or any drink that you otherwise regularly consume.  It’s such a simple way to do something beneficial for yourself without having to create a new daily routine. 

It’s the same thing as if you’re already taking a bunch of capsules or supplements.  If you just add a CBD supplement to your routine,  you’re not changing or creating new habits. At the end of the day,  the best type of CBD product is one that you’re actually going to take consistently. 

From another perspective, just looking at the specialty coffee and cafe industry,  we’re already starting to see a bit more of a customizable option appear on the menus where it’s not just coffees anymore. There are things like turmeric lattes, matcha lattes, you can add collagen plant-based milk, and all these different things to fine-tune the exact experience that you’re looking for and CBD is no exception.

CBD is really just another superfood that can give the user consuming that beverage certain types of benefits that they’re looking for.  However, most of the CBD out there is in oil form as in tinctures.  The oil is fine for those applications,  but as soon as you swallow CBD oil into the stomach the absorption rate or the bioavailability really gets called into question.

Unfortunately, CBD oil itself has very low absorption rates. We’re talking 10-20% so if you think you’re taking a 20-milligram dose, you might actually only be getting 2 milligrams absorbance to your body.

Therefore, if you’re going to be doing CBD coffee drinks or any CBD specialty drink,  it needs to be in some form that is converted for full absorption in the stomach. 

Ultimately, it needs to have increased bioavailability, and using a water-soluble form of CBD powder is the best way to go about it. The CBD water-soluble powder is designed for mixing into drinks effectively and also being effectively absorbed in the stomach. 

In summary, CBD and caffeine actually balance each other out so you still get the upbeat energetic effects but you’re not going to be anxious and feeling overwhelmed. The CBD cuts out on those negative side effects of the caffeine. If you will be putting CBD into your favorite beverage, please make sure that you’re using a water-soluble type of CBD so you can absorb the full dose and experience all the benefits.

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Water Soluble CBD

Millions of people from all over the world are discovering CBD for the first time

Odds are, they’re hearing about or using CBD in one of its many oil forms like a tincture, cream, or vape liquid. The vast majority of use cases out there are gonna be water-based, I’ll explain more about what I mean here in a bit. But what it all comes down to is bioavailability. 

So what does bioavailability mean? 

Simply put, it is the absorption percentage of the CBD which enters the circulation when introduced into the body and so is able to have an active effect. Therefore when using CBD, we want the highest bioavailability possible so our body can absorb all the benefits.

The First Pass Effect

The way in which you consume the CBD dictates how bioavailable it is. So the first thing that’s crucial to understanding why water-soluble is so important is known as the First Pass Effect or First Pass Metabolism. This is a physiological phenomenon that occurs when you’re delivering any drug compound to the body, the concentration gets greatly reduced before it can effectively be absorbed. 

Basically what’s happening is that this drug compound (CBD) is getting processed by the liver before it has a chance to effectively enter your bloodstream. This ends up meaning you have a great decrease in bioavailability. It’s not a novel problem, however. This concept affects tons of different drug compounds from curcumin (turmeric) to morphine; and various other substances that are standard in drug delivery and pharmaceuticals.  

These pharmaceutical compounds have the same exact issue which is the First Pass Effect, preventing it from being efficiently absorbed in a certain state.  So to overcome the effect, there needs to be some sort of conversion process for these molecules. 

Keep in mind that The First Pass Effect only affects the bioavailability of CBD if consumed into the stomach or oral consumption. If you’re absorbing a CBD oil tincture properly under your tongue through your skin, or you’re vaping it, it doesn’t have those absorption issues because the First Pass Effect is specific for the stomach.  

The good thing is that scientists have created techniques to successfully overcome the first pass effect. This means that you can take something like CBD which normally has extremely poor bioavailability in the stomach, and put it through this conversion process. Doing so will enable you to drink it, eat it, or swallow it into your stomach without sacrificing effectiveness. 

So why does all of this matter? 

It comes down to the fact that we can’t effectively absorb CBD in our stomach as is. You might be thinking well what about all the CBD oil capsules out there? Isn’t that just an oil that I’m swallowing into my stomach? Or what about CBD drinks, am I not getting the full dose for those either?

The answer really is it all depends on how those companies formulated their CBD. 

For example, there are some CBD companies that use a unique conversion process for their capsules and drinks. This ensures that your body is able to process the capsules or drinks without compromising the bioavailability levels. 

Unfortunately, there are a lot of CBD capsule companies out there that do not use these conversion techniques and this contributes to poor bioavailability levels. This is a science that not everybody’s aware of, or they are aware of it and have chosen to ignore it for some reason.

What does it look like if you took a 25 milligram CBD capsule?

You could only be absorbing 5 milligrams of that expected dose. Out there in the world of drug delivery science, up to 40% of new drug compounds–a lot of them being from plants, have this same issue of bioavailability in the stomach. The techniques that have been created to overcome this problem are tried and tested and well known in the scientific community and are being used every day for other compounds.

Maintaining bioavailability through conversion 

One of the best ways to overcome the first-pass effect is to convert the oil-soluble CBD into a water-soluble form. Doing this not only increases bioavailability in the stomach but it also greatly increases the ways in which you could use CBD products.

Because with an oil-based extract, you’re confined to mixing it with other oils since of course oil and water don’t mix.  With water-soluble, you can much more easily incorporate that into baked goods, frozen goods, coffee, tea, juices, and so much more.  

One technique being used at some CBD facilities is recognized for possessing the unparalleled potential for increasing the oral bioavailability of poorly water-soluble drugs. I know that’s a mouthful but basically it means that the technique converts the soil into a form that increases bioavailability in the stomach.

So how does this work? 

Basically you could think of CBD oil as a big blob and this conversion technique takes it from a big blob of oil and breaks it down into a bunch of really really really small pieces.  All of those small pieces are micro or nano-sized and that ends up being what’s known as microencapsulation. It is literally encapsulating pieces of that CBD oil into small enough segments so they can effectively enter your bloodstream in the stomach and overcome the first-pass effect.

The end result of the conversion process that we use to take the CBD oil into a water-soluble form ends up creating an off white powder.  It’s very fine to the touch and still has the smell from all the terpenes and other naturally occurring compounds in the extract besides the CBD.

Well maybe water-soluble CBD is not for you. If you really like creams, if you really like holding a tincture under your tongue-then by all means stick with that. However, if you want to expand the ways in which you can use this substance then water-soluble is for sure the way to go.

Otherwise, you’re gonna be throwing your CBD oil into your smoothie or into your water. First of all, it’s not gonna mix well.  Secondly, you’re gonna be absorbing maybe 50% less. To incorporate something and build it into your daily routine it has to be easy so water-soluble CBD allows you to just consume it in a much more friendly way. This eliminates having to guess what dose you’re expecting without having to sacrifice bioavailability and without having to deal with holding an oil under your tongue to properly absorb it.

Water-soluble CBD is all about convenience 

If you walked into any natural food store near you what you would see is powders that you could add to a shaker or smoothie, and you’d see pills. There are some tinctures, but there is a very small minority compared to what is in the supplement department as a whole.

So with either pills or powders, it’s entering your stomach. In order to use CBD in that same way, it really needs to be in a converted form for increased bioavailability and a water-soluble CBD can do that

If CBD is really going to go mainstream like we all know it can, it’s gonna be in the most user-friendly way. I think it makes the most sense that the most user-friendly way for CBD to be delivered to the body is just by swallowing it, drinking it, or using it in a capsule. 

You know there’s a lot of people out there that have great CBD tinctures but when they start dropping that tincture into a smoothie it’s misleading to their customers. Yes, the tincture is perfectly fine absorbed under the tongue. But if you’re just dropping CBD into your smoothie, you should be aware that you’re getting only half that dose or less.

A good example is if you go to fill your car up with gas and pay for a full tank would you be okay only getting half a tank or even 20% of a tank? Absolutely not so if you’re paying for a dose of CBD oil and you’re just putting it a drink or smoothie, you should know that’s exactly what’s happening. 

Conclusion

So that’s everything you need to know about water-soluble CBD. Really what it comes down to is we all have these incredible endocannabinoid systems in our body that are the precursor to our nervous and immune system. Our endocannabinoid system and the CBD which interact with it is essential for the full functioning of our body’s vital systems and maintaining health and balance within our body.

CBD is arguably the best way to supplement that system and support yourself on so many levels by helping the body achieve homeostasis. Being in homeostasis means the body is in balance. When we are in balance and our internal systems are working both efficiently and effectively, then we experience optimal health and wellness.

However you want to incorporate CBD into your life is up to you but just remember that if you’re going to be swallowing it in a capsule, or in any other form, it needs to be converted to overcome the first-pass effect. Taking CBD in a water-soluble powder helps to overcome that bioavailability obstacle and also greatly opens up the opportunities for you to use it in creative and interesting ways

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CBDMedic Product Review: Pros & Cons

In this CBDMedic review, I will be giving you both the pros and cons to using this popular range of CBD products so you can find out whether or not they are right for you.

Okay, let’s check out the pros of this product…

High Quality Natural Ingredients

Unfortunately, due to the growing buzz and popularity of cannabidiol or CBD, there are many shady companies popping up everywhere that are using low-quality ingredients. Many of which are sourced from plants grown in unknown areas where regulation and quality control is not as tight as the USA. 

Thankfully, CBDMedic uses only the highest quality natural ingredients. The most important of course is their actual CBD oil, which is grown in accordance with all federal and state laws. CBDMedic also doesn’t contain any steroids, synthetic fragrances, phthalates, parabens, petrolatum, or artificial dyes.

THC Free

All of the products in the CBDMedic lineup do not contain the psychoactive compound in cannabis called THC. So you’re not going to experience any type of high, you won’t become addicted, and you will not fail a THC drug test.

Powerful Topical Solutions

At the current time of writing this article, CBDMedic only deals with topical solutions for the face and body such as ointments, creams, sprays, roll-ons, and massage oils. I don’t know if they will ever create any other products such as edibles. Or they might just keep on sticking to what they excel at.

The CBDMedic product line can be divided up into two distinct categories-Pain Relief and Skincare. Within pain relief, there are products designed for back and neck pain, arthritis, muscle, and joint pain, foot pain, and massage amongst others. The skincare products deal with acne, eczema, itches, and rashes and there is also a facial cleanser.

Okay, let’s check out the cons of this product…

The Cost

The only real issue with this range of products is their cost. But this is definitely a case of you get what you paid for. High-quality hemp obviously costs more but has more benefits than a lower quality version which many other companies use today. So if you want the highest quality, these products are a great choice.

Overall, CBDMedic is one of the best topical CBD products on the market today. It contains super high-quality CBD from hemp and it’s perfect for anybody who deals with aches and pains from physical activity. The products are fast working and expertly created with the finest of ingredients.

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Does CBD oil work to stimulate hair growth?

In this article we will discuss how CBD can play a role in maintaining a healthy head of hair

According to the AHLA (American Hair Loss Association), about two thirds of men will see their luscious locks start to disappear by the age of 35.  Once guys turn 50, the number shoots up to 85%. So at the age of 50, 85% of men will notice a significant amount of hair loss or thinning hair. Not very encouraging statistics for all the guys out there. 

Now the most upsetting part is 25% of all men who experience hair loss actually experience it before the age of 21. Unfortunately for women, this condition doesn’t just affect men. About 40% of people who lose their hair are women.

Now whether you just start seeing hair fall down the drain or you’re trying to cover it up with a hat or a new hairstyle, hair loss is a daily challenge for anyone who’s experiencing it. 

I’m sure if you’re reading this article you already know that there are tons of treatments for hair loss including topical medication, pills, and all the way to hair transplants. Now I’m not saying that these treatments don’t work.

To a degree there are plenty of people that seem to get great results from some of these treatments. However what I have noticed is that these treatments don’t seem to last. 

In fact according to some of the leading medication companies including Rogaine or Finasteride, if you were to stop taking these medications after experiencing any sort of progress, your results will go in reverse twice as fast. So any effort that you did put into your hair will be all for naught. 

This brings me to my main point that if you’re going to try something to help stop hair loss or regrow your hair why not try the most natural way possible? Which right now is CBD oil. So before I get into how CBD could potentially help you with hair loss, let me first explain why hair loss happens into the first place.

People typically lose about a hundred hairs a day, which usually doesn’t cause any noticeable thinning on the scalp and this is due to new hair growing and at the same time that you’re losing it. 

Hair in a follicle typically goes through a growth cycle that lasts about two to six years. Even if you shave or cut your hair the same hair will grow back out of the follicle from the root of the hair contained within the follicle. 

Now at the end of the cycle, the hair enters what’s known as a resting phase before finally falling out a few months later then the follicle produces a new hair and the cycle begins again. 

Unfortunately, high levels of hormones including DHT or dihydrotestosterone which is created from testosterone can shrink your hair follicles as well as shorten the cycle causing the hair to grow out looking thinner and more brittle. In addition, it contributes to hair falling out much faster. 

Now that we know some basics about hair loss, let’s talk a little bit more about CBD oil and how it may help you with your hair loss. I will say that CBD oil is not going to go into your hair follicle or strand and magically make it longer and thicker. However, I will say what CBD does is it puts your body in the ideal condition for maximum hair growth. 

If you just started to notice a receding hairline or maybe you’re losing more hair in the shower that you normally do, I would say now is the perfect time to add CBD to your daily routine. Doing so will get yourself into the best possible state in order to get the most healthy head of hair possible. 

I’m sure you’re probably wondering how so let me give you some examples. CBD oil can provide restful sleep and less stress but how’s that gonna help with hair loss? Well, deep restful sleep will help reduce your levels of cortisol which is the stress hormone and has been linked to higher levels of hair loss. So less cortisol means less hair loss.  

CBD oil can also reduce inflammation. Now many of you may not know this but chronic inflammation significantly impacts your hair’s health and growth. CBD oil not only helps suppress inflammation in the body, it is also suspected to reach sebaceous glands which secrete oil that lubricates hair where it can provide therapeutic benefits.

My last example is CBD oil increases blood circulation so obviously increased blood circulation is going to have many benefits including causing more stimulation to your scalp. Especially given the fact that CBD increases cerebral blood flow, it helps deliver more nutrients to hair follicles. This removes harmful toxins allowing hair to become stronger and healthier to promote new hair growth.

So basically if you’re experiencing hair loss or maybe even just a little thinning, I would say that making CBD a part of your daily routine is definitely a good idea. Now don’t worry I’m not just gonna leave you hanging with that.

I have included links below to some of the best CBD oils on the market that have tons of verified reviews and lab reports this way you know you are getting the highest quality possible. 

Lazarus Naturals- use coupon code “ofcbdoil”

Joy Organics 

CBD Medic

Pure Relief

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What you need to know about CBD Dog Treats

In the following article we will be covering:

*A brief overview of CBD 

*Reviewing the seven main CBD benefits 

*CBD dog treat dosage guidelines  

*Which CBD dog brands you can actually trust 

CBD stands for Cannabidiol and the cannabis plant has hundreds of cannabinoids which have many potential benefits. What’s great about the pet products with CBD is that many contain zero THC which means they have no negative psychoactive effects. 

CBD is actually very well tolerated by pets and has extremely rare cases of side effects so it is very safe. CBD interacts with the endocannabinoid system in dogs and all mammals have the system.

If you really want to learn everything about this system please check out our article on the endocannabinoid system here

The endocannabinoid system helps manage many different processes and CBD that your dog consumes interacts with this system and this has been shown to produce many different health benefits. 

One of the main CBD health benefits is as a powerful painkiller and studies show that CBD can help manage pain in many different ways.  A lot of pet owners are using CBD for their dogs because they’re going through pain whether it’s from a surgery, from an illness, or lack of mobility pain in their joints.  

Perhaps one of the best known medicinal uses for CBD is its ability to help control seizures tremors and things of that nature. That’s because CBD it’s a natural anticonvulsant. So if your dog has seizures or epilepsy many dogs have seen really great results after using CBD, whether that’s reducing the frequency and/or the severity of the seizures. 

Now it doesn’t totally cure this in every single dog but there are so many dogs that are seeing great benefits from CBD and struggling with seizures.

CBD also has anti-inflammatory properties.  It’s effects are believed to be one of the reasons why this compound is used in treating so many different conditions. Inflammation can be in the joints but it can also be in other illnesses as well.

CBD also reduces anxiety and stress in some pets. Many studies have shown the CBD can help manage the symptoms from a variety of mental conditions including anxiety. 

There’s also a strong body of evidence that shows that CBD is a successful antiemetic, controlling both nausea and vomiting. So if your dog gets carsick CBD can definitely help. 

CBD may also slow tumor growth and can help protect against colon cancer in rats by stopping the development and growth and spread of malignant tumors. Lastly, CBD promotes homeostasis to give the body an overall sense of well-being and balance. 

It helps with so many different things that many pet owners simply choose CBD not only as a medicine to treat specific illnesses, but also as a regular supplement to promote overall health and well-being.

So you might be wondering why CBD treats? Well when most people think of CBD they probably think of CBD oils and these are still the most popular form of CBD. Administering them requires you to apply a few drops under your pets tongue.

CBD treats simply offer a great alternative to oils and there are two main reasons that I want to highlight.  One is convenience, and the other is specific ingredients. Some dogs just don’t like the taste of CBD oil.

If you have a picky eater then you might find it quite difficult to administer the oil under their tongue. Now if you bought some oil and you are having trouble with this, you can always just put a few drops directly on their food and this certainly works.

However, if you need a new supply of CBD, treats do make a great alternative to oils because they’re just so easy to administer. It’s as simple as giving your dog a treat.

Now the other benefit with treats is that you can often order a type which targets very specific ailments and symptoms. The reason is that CBD treats will contain other ingredients which are believed to also help a particular ailment or condition that your dog might have.  

For example, calming treats may contain things like valerian root, passion flower and chamomile so these together with CBD may offer support for dogs who are stressed out and anxious. 

Mobility treats may contain things like Glucosamine, Turmeric and Boswellia. These ingredients together with CBD may support relieving pain associated with inflammation.

Heart, immune care, and cognition treats may contain things like omega-3 fatty acids, elderberry, and blueberry so these are great for aging dogs.

So now we’re going to talk about dosing CBD treats. CBD dosing seems to be a very common question among pet owners. One reason I believe is that there are so many CBD oils and different brands out there and they all offer slightly different guidelines.

This can be much more confusing when pet owners buy CBD oil which is intended for humans and then try to figure out a proper dosage for their dog. Here’s the bottom line advice for dosing with CBD oil and CBD treats, just follow the guidelines from the manufacturer.

However it’s important to note that you should be buying CBD for your pet from a trusted pet CBD company. Every CBD oil has a different concentration and every CBD cookie or treat does as well. That is why it is so important buy your CBD treats from a reputable brand. The company will have very clear instructions on how much you need to give your dog and it’s really that simple.

If you’re using CBD on your dog and after a couple weeks you’re just not seeing any results with the regular dose then you can certainly jump up to the stronger dose.  So if you had a dog who’s about 30 pounds and you’re not seeing results then simply jump up to the stronger dose and that would be three treats per day from this particular brand using their particular treats. 

If you have a larger dog that weighs over 50 pounds they recommend about 4 treats per day.  If you’re gonna use CBD oils it goes the same way, Holista Pet has dosing instructions and a chart that you can reference as well.

You might be wondering which brand is the best and the truth is we’ve been testing out CBD pet products for quite a few years now on our website we review various brands and we test these products on our own dogs. 

I also get feedback from thousands of pet owners who are in our Facebook group who I interact with on email and we really get to find out which brands are the best and we’re always testing out new brands.

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